Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Caspases are cysteine-dependent aspartate-specific proteases that play a vital function in apoptosis (or programmed cell dying) and inflammation. Based on their perform, caspases are majorly categorized into apoptotic (initiator/apical and effector/executioner) and inflammatory caspases. Caspases bear transition from an inactive zymogen to an active caspase to perform their perform. This transition calls for structural rearrangements that are most outstanding on the active website loops and are crucial for the catalytic exercise of caspases. In effector caspase-3, the structural rearrangement within the active website loop is proven to be facilitated by a set of invariant water (IW) molecules.

However, the atomic particulars involving their function in stabilizing the active conformation haven’t been reported but. Moreover, it isn’t identified whether or not water molecules are important for the active conformation in all caspases. Thus, on this examine, we positioned IW molecules in initiator, effector, and inflammatory caspases to grasp their exact function in rendering the structural association of active caspases. Furthermore, IW molecules concerned in anchoring the fragments of the protomer and rendering regulated flaccidity to caspases have been recognized. Location and identification of IW molecules interacting with amino acid residues concerned in establishing the active conformation within the caspases may facilitate the design of potent inhibitors throughout up-regulated caspase exercise in neurodegenerative and immune problems. Communicated by Ramaswamy H. Sarma.

Meanwhile, compounds 2a and 2b skilled excellent exercise towards each Gram-positive and Gram-negative microorganisms. Interestingly, compound 2j skilled excessive exercise towards Escherichia coli and Pseudomonas aeruginosa with MIC of 0.036 and 0.043, respectively. Compound 2nd revealed 27 folds and 22 folds, respectively growing of exercise over ciprofloxacin towards Staphylococcus aureus and MRSA(reference pressure). Compound 2nd confirmed excessive exercise towards Staphylococcus aureus, MRSA (reference pressure) and MRSA (scientific pressure) with MIC of 0.57, 0.52, 0.082 µg/mL, respectively.

Interestingly, essentially the most active examined compounds have been discovered to have promising physicochemical and drug likeness properties. The Mannich bases 2j, 2nd and 2g confirmed promising antibacterial actions, whereas naphthols 2a and 2b confirmed promising antiproliferative and antibacterial actions that require additional optimization.

Therapeutic potential of α,β-thujone by metabolic reprogramming and caspase-dependent apoptosis in ovarian most cancers cells

 

The therapeutic potential of α,β-thujone, a purposeful compound discovered in lots of medicinal vegetation of the Cupressaceae, Asteraceae, and Lamiaceae households, has been demonstrated, together with in inflammation and cancers. However, its pharmacological features and mechanisms of motion in ovarian most cancers stay unclear. We investigated the anticancer properties of α,β-thujone in ES2 and OV90 human ovarian most cancers cells and its impact on sensitization to cisplatin. α,β-thujone inhibited most cancers cell proliferation and induced cell dying by caspase-dependent intrinsic apoptotic pathways.

Moreover, α,β-thujone-mediated endoplasmic reticulum stress was related to the loss of mitochondrial features and altered metabolic panorama of ovarian most cancers cells. α,β-Thujone attenuated blood vessel formation in transgenic zebrafish, implying it has vital antiangiogenic potential. In addition, α,β-thujone sensitized ovarian most cancers cells to cisplatin, inflicting synergistic pharmacological results. Collectively, our outcomes counsel that α,β-thujone has therapeutic potential in human ovarian most cancers and features through regulating a number of intracellular stress-associated metabolic reprogramming and caspase-dependent apoptotic pathways.

Lung most cancers has the very best incidence and cancer-related mortality of all cancers worldwide. Its remedy is targeted on molecular focused remedy. c-MET performs an vital function within the improvement and metastasis of numerous human cancers and has been recognized as a pretty potential anti-cancer goal. Podophyllotoxin (PPT), an aryltetralin lignan remoted from the rhizomes of Podophyllum species, has a number of pharmacological actions that embody anti-viral and anti-cancer results. However, the mechanism of the anti-cancer results of PPT on gefitinib-sensitive (HCC827) or -resistant (MET-amplified HCC827GR) non-small cell lung most cancers (NSCLC) cells stays unexplored.

Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Bta-miR-98 Suppresses Replication of Caprine Parainfluenza Virus Type 3 Through Inhibiting Apoptosis by Targeting Caspase-3

 

Caprine parainfluenza virus sort 3 (CPIV3) is an rising respiratory pathogen that impacts the sheep and goat trade in China and probably different nations world wide. Accumulating proof means that microRNAs play vital roles in regulating virus-host interactions and can suppress or facilitate viral replication. In this examine, we confirmed that CPIV3 an infection induced apoptosis in Madin-Darby bovine kidney (MDBK) cells, as decided by morphological modifications and circulation cytometry.

Caspase exercise and the expression of pro-apoptotic genes additional indicated that CPIV3 induced apoptosis by activating each the intrinsic and extrinsic pathways. We additionally demonstrated the involvement of bta-microRNA-98 (bta-miR-98) in regulating CPIV3-induced apoptosis. Bta-miR-98 was downregulated in MDBK cells contaminated with CPIV3. Overexpression of bta-miR-98 considerably decreased the actions of caspase-3, -8, and -9. Conversely, inhibition of bta-miR-98 had fully reverse results. Furthermore, our information confirmed that bta-miR-98 markedly affected CPIV3 replication by regulating apoptosis. Importantly, we discovered that bta-miR-98 modulated CPIV3-induced apoptosis by focusing on caspase-3, an effector of apoptosis.

Active Human Caspases Group III

K2063-100 4x25 units
EUR 641

Active Human Caspases Set III

K232-8-25
EUR 838

Active Human Caspases Group I, Active Human

K241-3-25
EUR 370

Active Human Caspases Set I

K230-4-25
EUR 479

Active Human Caspases Set II

K231-4-25
EUR 512

Active Human Caspases Group IV

K2060-250 10x25 units
EUR 1225

Active Human Caspases Set IV

K233-10-25
EUR 968

Acc III unit: 25

YRACC3 1 vial Ask for price

Caspases Group II, Activ Human

K242-3-25
EUR 403

Human Kinase Library III

HKIN-III 1 set
EUR 450

Aligner 25-36

KS072012-III 1 Kit
EUR 412
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Afl II unit: 25

YRAFL2 1 vial Ask for price

Hae III unit: 3400

YRHAE3 1 vial Ask for price

Hind III unit: 12000

YRHIND3 1 vial Ask for price

Active Interleukin 25 (IL25)

4-APB694Hu01
  • EUR 637.60
  • EUR 274.00
  • EUR 2116.00
  • EUR 772.00
  • EUR 1444.00
  • EUR 490.00
  • EUR 5140.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9H293
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 18.5kDa
  • Isoelectric Point: 8.6
Description: Recombinant Human Interleukin 25 expressed in: E.coli

Chicken Caspases 3(Caspases 3) ELISA Kit

QY-E80112 96T
EUR 426

Human Interleukin 25 (IL25) Protein (Active)

20-abx651392
  • EUR 885.00
  • EUR 328.00
  • EUR 2834.00
  • EUR 1052.00
  • EUR 606.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

RapidSeq High Yield Directional mRNA Sample Prep Kit - With Aligner 25-36

KS073012-III 1 Kit
EUR 1142
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

RapidSeq High Yield Small RNA Sample Prep Kit - With Aligner 25-36

KS074012-III 1 Kit
EUR 1021
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Hae III-HC unit: 3400, High Concentration

YRHAE3-HC 1 vial Ask for price

Hind III -HC unit: 12000, High Concentration

YRHIND3-HC 1 vial Ask for price

Angiotensin III (human, mouse)

A1043-25 25 mg
EUR 131
Description: Angiotensin III (Asp | Arg-Val-Tyr-Ile-His-Pro-Phe) is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system by angiotensinases located in red blood cells and the vascular beds of most tissues.

PIK-III

B6160-25 25 mg
EUR 615
Description: IC50: 18 nM for VPS34PIK-III is a VPS34 inhibitor and is able to inhibit autophagy.

MIF Human, Macrophage Migration Inhibitory Factor Human Recombinant Protein (Active)

PROTP14174-4 Regular: 3x10ug
EUR 317
Description: MIF human Recombinant was cloned into an E.coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques.;Macrophage Inducing Factor Human Recombinant is a single, non-glycosylated, polypeptide chain containing 115 amino acids and having a molecular mass of 12.5 kDa.

Active Sonic Hedgehog (SHH), human recombinant

4010-25
EUR 327

Neuronal Transdifferentiation Modulators Set III

K874-4
EUR 414

Human Phospholipase A2, Group III (PLA2G3) Protein

20-abx650483
  • EUR 704.00
  • EUR 286.00
  • EUR 2165.00
  • EUR 829.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

AP-III-a4

B3588-25 25 mg
EUR 1198

10-Deacetylbaccatin III

B2659-25 25 mg
EUR 510

AKR1C3 Inhibitor III

2424-25
EUR 436

His-tag Protein Purification RefreshBuffer Set unit: 25 Preps

FYP101-25P 1 vial Ask for price

Human Caspases 3/7 Elisa Kit

QY-E05405 96T
EUR 361

Amyloid Beta-peptide (25-35) (human)

A1039-25 25 mg
EUR 505
Description: Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-GlyAmyloid- ? (A?) peptide is commonly found in human Alzheimer?s disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of A? in the human brain are A? (1-40) and A? (1-42).

Anti-active + pro Caspase 3 Rabbit Monoclonal Antibody

M00334-4 100ug/vial
EUR 397
Description: Rabbit Monoclonal active + pro Caspase 3 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

CST3 Mouse, Cystatin-C Mouse Recombinant Protein, Active

PROTP21460-4 Regular: 10ug
EUR 317
Description: CST3 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140 a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

IL-4 Interleukin 4 Human Recombinant Protein, Yeast

PROTP05112-4 Regular: 10ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques.

Active Interleukin 4 (IL4)

4-APA077Hu01
  • EUR 665.38
  • EUR 281.00
  • EUR 2220.16
  • EUR 806.72
  • EUR 1513.44
  • EUR 508.00
  • EUR 5400.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q5W4U1
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 16.6kDa
  • Isoelectric Point: 9.3
Description: Recombinant Human Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)

4-APA077Hu61
  • EUR 782.75
  • EUR 313.00
  • EUR 2660.32
  • EUR 953.44
  • EUR 1806.88
  • EUR 587.00
  • EUR 6500.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q5W4U1
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 16.6kDa
  • Isoelectric Point: 9.3
Description: Recombinant Human Interleukin 4 expressed in: 293F cell

Active Interleukin 4 (IL4)

4-APA077Mu01
  • EUR 651.04
  • EUR 277.00
  • EUR 2166.40
  • EUR 788.80
  • EUR 1477.60
  • EUR 499.00
  • EUR 5266.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P07750
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 43.6kDa
  • Isoelectric Point: 8.1
Description: Recombinant Mouse Interleukin 4 expressed in: E.coli

Active Interleukin 4 (IL4)

4-APA077Ra01
  • EUR 829.34
  • EUR 325.00
  • EUR 2835.04
  • EUR 1011.68
  • EUR 1923.36
  • EUR 618.00
  • EUR 6937.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P20096
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 35.7kDa
  • Isoelectric Point: 8.4
Description: Recombinant Rat Interleukin 4 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Glypican 4 (GPC4)

4-APA998Mu01
  • EUR 835.62
  • EUR 327.00
  • EUR 2858.56
  • EUR 1019.52
  • EUR 1939.04
  • EUR 622.00
  • EUR 6996.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P51655
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): Inquire
  • Isoelectric Point: 6.5
Description: Recombinant Mouse Active Glypican 4 (GPC4) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Elastase 4 (ELA4)

4-APB310Ra01
  • EUR 772.00
  • EUR 310.00
  • EUR 2620.00
  • EUR 940.00
  • EUR 1780.00
  • EUR 580.00
  • EUR 6400.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P55091
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 30.2kDa
  • Isoelectric Point: 5.9
Description: Recombinant Rat Elastase 4 expressed in: E.coli

Recombinant (sf9) Human FcGR2a/CD32 Protein (166Arg, 1-216aa, >95%, his-tag, ~25 kda, low endotoxins), active

FCGR2A21-R-25 25 ug
EUR 347

Fluorescein Active Caspase Staining Kit

K2047-25 25 assays
EUR 238

Red Active Caspase Staining Kit

K2052-25 25 assays
EUR 238

Active Caspase-1, rat recombinant

7524-25
EUR 338

MTBK_20640-25

AR02-P0011-25 25ug
EUR 473

Active High Mobility Group Protein 1 (HMG1)

4-APA399Hu02
  • EUR 906.40
  • EUR 346.00
  • EUR 3124.00
  • EUR 1108.00
  • EUR 2116.00
  • EUR 670.00
  • EUR 7660.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P09429
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 21.7kDa
  • Isoelectric Point: 9.7
Description: Recombinant Human High Mobility Group Protein 1 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active High Mobility Group Protein 1 (HMG1)

4-APA399Hu61
  • EUR 637.60
  • EUR 274.00
  • EUR 2116.00
  • EUR 772.00
  • EUR 1444.00
  • EUR 490.00
  • EUR 5140.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P09429
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 51.2kDa
  • Isoelectric Point: 5.6
Description: Recombinant Human High Mobility Group Protein 1 expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active High Mobility Group Protein 1 (HMGB1)

4-APA399Mu02
  • EUR 933.28
  • EUR 353.00
  • EUR 3224.80
  • EUR 1141.60
  • EUR 2183.20
  • EUR 688.00
  • EUR 7912.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P63158
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 21.7kDa
  • Isoelectric Point: 9.7
Description: Recombinant Mouse High Mobility Group Protein 1 expressed in: E.coli

Recombinant Phospholipase A2, Group III (PLA2G3)

4-RPD831Hu01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q9NZ20
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 31.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Phospholipase A2, Group III expressed in: E.coli

Recombinant Phospholipase A2, Group III (PLA2G3)

4-RPD831Ra01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: D3ZGN6
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 31.4kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Phospholipase A2, Group III expressed in: E.coli

Phospholipase A2, Group III (PLA2G3) Antibody

20-abx131085
  • EUR 328.00
  • EUR 133.00
  • EUR 871.00
  • EUR 453.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Phospholipase A2, Group III (PLA2G3) Antibody

20-abx131086
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Phospholipase A2, Group III (PLA2G3) Antibody

abx030609-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Phospholipase A2, Group III (PLA2G3) Antibody

abx030609-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Phospholipase A2, Group III (PLA2G3) Antibody

20-abx178002
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Phospholipase A2, Group III (PLA2G3) Antibody

20-abx178003
  • EUR 1233.00
  • EUR 592.00
  • 1 mg
  • 200 ug
  • Please enquire.

Human Interleukin 4 (IL4) Protein (Active)

20-abx651394
  • EUR 913.00
  • EUR 328.00
  • EUR 2973.00
  • EUR 1107.00
  • EUR 634.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human Interleukin 4 (IL4) Protein (Active)

20-abx651395
  • EUR 1080.00
  • EUR 398.00
  • EUR 3557.00
  • EUR 1302.00
  • EUR 732.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human Neurotrophin 4 (NT4) Protein (Active)

20-abx655787
  • EUR 1149.00
  • EUR 411.00
  • EUR 3850.00
  • EUR 1400.00
  • EUR 787.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Human Syndecan 4 (SDC4) Protein (Active)

20-abx655831
  • EUR 913.00
  • EUR 328.00
  • EUR 2973.00
  • EUR 1107.00
  • EUR 634.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Heparin-Binding Peptide III

1823-25
EUR 387

MMP-III Inhibitor, NNGH

2569-25
EUR 457

Agouti-related Protein (AGRP) (25-82), human

A1134-25 25 mg
EUR 1511
Description: Agouti-related protein also called Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesised in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus(1).

Fluorescein Active Caspase-12 Staining Kit

K2046-25 25 assays
EUR 238

Fluorescein Active Caspase-2 Staining Kit

K2048-25 25 assays
EUR 238

Fluorescein Active Caspase-3 Staining Kit

K2049-25 25 assays
EUR 238

Fluorescein Active Caspase-8 Staining Kit

K2050-25 25 assays
EUR 238

Fluorescein Active Caspase-9 Staining Kit

K2051-25 25 assays
EUR 238

Red Active Caspase-3 Staining Kit

K2053-25 25 assays
EUR 238

Red Active Caspase-8 Staining Kit

K2054-25 25 assays
EUR 238

Red Active Caspase-9 Staining Kit

K2055-25 25 assays
EUR 238

CaspGLOW? Fluorescein Active Caspase Staining Kit

K180-25
EUR 234

CaspGLOW? Red Active Caspase Staining Kit

K190-25
EUR 240

Human High Mobility Group Protein 1 (HMG1) Protein (Active)

20-abx651348
  • EUR 1233.00
  • EUR 439.00
  • EUR 4170.00
  • EUR 1497.00
  • EUR 829.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Phospholipase A2, Group III (PLA2G3) Polyclonal Antibody (Human)

4-PAD831Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: PLA2G3 (Gly20~Val268)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Phospholipase A2, Group III (PLA2G3)

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

RD-PLA2G3-Hu-48Tests 48 Tests
EUR 521

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

RD-PLA2G3-Hu-96Tests 96 Tests
EUR 723

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

DLR-PLA2G3-Hu-48T 48T
EUR 517
  • Should the Human Phospholipase A2, Group III (PLA2G3) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Phospholipase A2, Group III (PLA2G3) in samples from serum, plasma or other biological fluids.

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

DLR-PLA2G3-Hu-96T 96T
EUR 673
  • Should the Human Phospholipase A2, Group III (PLA2G3) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Phospholipase A2, Group III (PLA2G3) in samples from serum, plasma or other biological fluids.

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

RDR-PLA2G3-Hu-48Tests 48 Tests
EUR 544

Human Phospholipase A2, Group III (PLA2G3) ELISA Kit

RDR-PLA2G3-Hu-96Tests 96 Tests
EUR 756

Fatty Acid Amide Hyrdrolase 1 (FAAH1), Active, Human Recombinant

P1257-25
EUR 479

Human Procollagen III N-Terminal Propeptide (PIIINP) Protein (Active)

20-abx655809
  • EUR 1177.00
  • EUR 425.00
  • EUR 3947.00
  • EUR 1428.00
  • EUR 801.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Rv0351 (GrpE)-25

AR02-P0003-25 25ug
EUR 126

Rv1009 (RpfB)-25

AR02-P0006-25 25ug
EUR 473

Rv2450c (RpfE)-25

AR02-P0007-25 25ug
EUR 473

Rv3875 (esxA)-25

AR02-P0008-25 25ug
EUR 473

Rv2031c(HspX)-25

AR02-P0009-25 25ug
EUR 473

Rv3131 (NfnB)-25

AR02-P0010-25 25ug
EUR 473

26795 25 CLOSURE NTRL 25MM

26795-25 50/pk
EUR 96
Description: Disposable Screw Cap Culture Tubes; Poly Closures

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

NF-?B Activation Inhibitor III

C3559-25 25 mg
EUR 457
Description: NF-?B Activation Inhibitor III is a NF-?B inhibitor.NF-?B (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex controling transcription of DNA, cytokine production as well as cell survival.

CaspGLOW? Fluorescein Active Caspase-12 Staining Kit

K172-25
EUR 234

CaspGLOW? Fluorescein Active Caspase-2 Staining Kit

K182-25
EUR 234

Collectively, our outcomes might counsel that CPIV3 an infection induced apoptosis and downregulated the degrees of bta-miR-98, and this miRNA regulated viral replication by effected apoptosis. This examine contributes to our understanding of the molecular mechanisms underlying CPIV3 pathogenesis. Essential oil (EO) fractions of vegetation are complicated mixtures of unstable compounds with broad-spectrum organic properties. In the present examine, the EO content material of Vitex agnus castus L. (VAC) leaves rising within the Aegean area of Turkey was extracted and recognized. Then, VAC EOs have been investigated for their potential antioxidant, cytotoxic and apoptotic results in human H69AR multi-drug resistant most cancers cells.