Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Caspases are cysteine-dependent aspartate-specific proteases that play a vital function in apoptosis (or programmed cell dying) and inflammation. Based on their perform, caspases are majorly categorized into apoptotic (initiator/apical and effector/executioner) and inflammatory caspases. Caspases bear transition from an inactive zymogen to an active caspase to perform their perform. This transition calls for structural rearrangements that are most outstanding on the active website loops and are crucial for the catalytic exercise of caspases. In effector caspase-3, the structural rearrangement within the active website loop is proven to be facilitated by a set of invariant water (IW) molecules.

However, the atomic particulars involving their function in stabilizing the active conformation haven’t been reported but. Moreover, it isn’t identified whether or not water molecules are important for the active conformation in all caspases. Thus, on this examine, we positioned IW molecules in initiator, effector, and inflammatory caspases to grasp their exact function in rendering the structural association of active caspases. Furthermore, IW molecules concerned in anchoring the fragments of the protomer and rendering regulated flaccidity to caspases have been recognized. Location and identification of IW molecules interacting with amino acid residues concerned in establishing the active conformation within the caspases may facilitate the design of potent inhibitors throughout up-regulated caspase exercise in neurodegenerative and immune problems. Communicated by Ramaswamy H. Sarma.

Meanwhile, compounds 2a and 2b skilled excellent exercise towards each Gram-positive and Gram-negative microorganisms. Interestingly, compound 2j skilled excessive exercise towards Escherichia coli and Pseudomonas aeruginosa with MIC of 0.036 and 0.043, respectively. Compound 2nd revealed 27 folds and 22 folds, respectively growing of exercise over ciprofloxacin towards Staphylococcus aureus and MRSA(reference pressure). Compound 2nd confirmed excessive exercise towards Staphylococcus aureus, MRSA (reference pressure) and MRSA (scientific pressure) with MIC of 0.57, 0.52, 0.082 µg/mL, respectively.

Interestingly, essentially the most active examined compounds have been discovered to have promising physicochemical and drug likeness properties. The Mannich bases 2j, 2nd and 2g confirmed promising antibacterial actions, whereas naphthols 2a and 2b confirmed promising antiproliferative and antibacterial actions that require additional optimization.

Therapeutic potential of α,β-thujone by metabolic reprogramming and caspase-dependent apoptosis in ovarian most cancers cells

 

The therapeutic potential of α,β-thujone, a purposeful compound discovered in lots of medicinal vegetation of the Cupressaceae, Asteraceae, and Lamiaceae households, has been demonstrated, together with in inflammation and cancers. However, its pharmacological features and mechanisms of motion in ovarian most cancers stay unclear. We investigated the anticancer properties of α,β-thujone in ES2 and OV90 human ovarian most cancers cells and its impact on sensitization to cisplatin. α,β-thujone inhibited most cancers cell proliferation and induced cell dying by caspase-dependent intrinsic apoptotic pathways.

Moreover, α,β-thujone-mediated endoplasmic reticulum stress was related to the loss of mitochondrial features and altered metabolic panorama of ovarian most cancers cells. α,β-Thujone attenuated blood vessel formation in transgenic zebrafish, implying it has vital antiangiogenic potential. In addition, α,β-thujone sensitized ovarian most cancers cells to cisplatin, inflicting synergistic pharmacological results. Collectively, our outcomes counsel that α,β-thujone has therapeutic potential in human ovarian most cancers and features through regulating a number of intracellular stress-associated metabolic reprogramming and caspase-dependent apoptotic pathways.

Lung most cancers has the very best incidence and cancer-related mortality of all cancers worldwide. Its remedy is targeted on molecular focused remedy. c-MET performs an vital function within the improvement and metastasis of numerous human cancers and has been recognized as a pretty potential anti-cancer goal. Podophyllotoxin (PPT), an aryltetralin lignan remoted from the rhizomes of Podophyllum species, has a number of pharmacological actions that embody anti-viral and anti-cancer results. However, the mechanism of the anti-cancer results of PPT on gefitinib-sensitive (HCC827) or -resistant (MET-amplified HCC827GR) non-small cell lung most cancers (NSCLC) cells stays unexplored.

Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Bta-miR-98 Suppresses Replication of Caprine Parainfluenza Virus Type 3 Through Inhibiting Apoptosis by Targeting Caspase-3

 

Caprine parainfluenza virus sort 3 (CPIV3) is an rising respiratory pathogen that impacts the sheep and goat trade in China and probably different nations world wide. Accumulating proof means that microRNAs play vital roles in regulating virus-host interactions and can suppress or facilitate viral replication. In this examine, we confirmed that CPIV3 an infection induced apoptosis in Madin-Darby bovine kidney (MDBK) cells, as decided by morphological modifications and circulation cytometry.

Caspase exercise and the expression of pro-apoptotic genes additional indicated that CPIV3 induced apoptosis by activating each the intrinsic and extrinsic pathways. We additionally demonstrated the involvement of bta-microRNA-98 (bta-miR-98) in regulating CPIV3-induced apoptosis. Bta-miR-98 was downregulated in MDBK cells contaminated with CPIV3. Overexpression of bta-miR-98 considerably decreased the actions of caspase-3, -8, and -9. Conversely, inhibition of bta-miR-98 had fully reverse results. Furthermore, our information confirmed that bta-miR-98 markedly affected CPIV3 replication by regulating apoptosis. Importantly, we discovered that bta-miR-98 modulated CPIV3-induced apoptosis by focusing on caspase-3, an effector of apoptosis.

Caspases Group III, Active Human

K243-4-25 each
EUR 614.4

Active Human Caspases Group IV

K2060-250 10x25 units
EUR 1470

Active Human Caspases Group I, Active Human

K241-3-25 each
EUR 444

Active Human Caspases Set III

K232-8-25 each
EUR 1005.6

Caspases Group II, Activ Human

K242-3-25 each
EUR 483.6

Active Human Caspases Set II

K231-4-25 each
EUR 614.4

Active Human Caspases Set IV

K233-10-25 each
EUR 1161.6

Active Human Caspases Set I

K230-4-25 each
EUR 574.8

Chicken Caspases 3(Caspases 3) ELISA Kit

QY-E80112 96T
EUR 511.2

Caspase-4, human recombinant, active

BC-120 25 U
EUR 507

Caspase-4, human recombinant active

BC-121 100 U
EUR 675

Human Caspases 3/7 Elisa Kit

QY-E05405 96T
EUR 433.2

Caspase-1, human recombinant, active

BC-116 25 U
EUR 577

Caspase-1, human recombinant, active

BC-117 100 U
EUR 822

Caspase-2, human recombinant, active

BC-118 25 U
EUR 531

Caspase-2, human recombinant, active

BC-119 100 U
EUR 782

Caspase-9, human recombinant, active

BC-124 25 U
EUR 574

Human Active caspase 3 ELISA kit

E01A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Active caspase 3 ELISA kit

E01A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Active caspase 3 ELISA kit

E01A0015 96T
EUR 700
Description: ELISA

Human Active caspase 1 ELISA kit

E01A1571 96T
EUR 700
Description: ELISA

Human Active Caspase 9 ELISA kit

E01A1644 96T
EUR 700
Description: ELISA

Caspase-3, active

RA15046 50 ug
EUR 459.6

Active Caspase-3

E8ET1602-47 100ul
EUR 275
Description: Available in various conjugation types.

Magic Red™ Caspases 3&7

KF17306 25 Tests
EUR 342

Magic Red™ Caspases 3&7

KF17307 100 Tests
EUR 834

Acc III unit: 25

YRACC3 1 vial Ask for price

Anti Caspase-3 active

CAS3PU 0,1 mg
EUR 258.12

Active Caspase 1 (CASP1)

4-APB592Ra01
  • EUR 1109.18
  • EUR 420.00
  • EUR 3829.44
  • EUR 1356.48
  • EUR 2592.96
  • EUR 818.40
  • EUR 9393.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Caspase 1 expressed in: E.coli

Active Caspase 1 (CASP1)

RPU54928-100ug 100ug
EUR 1133

Active Caspase 1 (CASP1)

RPU54928-1mg 1mg
EUR 5023.2

Active Caspase 1 (CASP1)

RPU54928-50ug 50ug
EUR 910.8

Active Caspase 3 (CASP3)

RPU56326-100ug 100ug
EUR 812.9

Active Caspase 3 (CASP3)

RPU56326-1mg 1mg
EUR 3603.6

Active Caspase 3 (CASP3)

RPU56326-50ug 50ug
EUR 653.4

Active Caspase 3 (CASP3)

APA626Hu01 10ug
EUR 264

Active Caspase 3 (CASP3)

APA626Ra03 10ug
EUR 276

Active Caspase 1 (CASP1)

APB592Ra01 10ug
EUR 368

active+pro Caspase 3

E8ET1608-64 100ul
EUR 275
Description: Available in various conjugation types.

Caspase-9 (Active) Antibody

3149-100 each
EUR 614.4

Caspase-6 (Active) Antibody

3156-100 each
EUR 535.2

Caspase-3 (Active) Antibody

3015-100 each
EUR 627.6

Caspase-3 (Active) Antibody

3015-30T each
EUR 268.8

Active Caspase-3 Antibody

20-abx125287
  • EUR 710.40
  • EUR 1028.40
  • EUR 493.20
  • 100 ul
  • 200 ul
  • 50 ul

Caspase-8 (Active) Antibody

3259-100 each
EUR 405.6

Caspase-8 (Active) Antibody

3259-30T each
EUR 175.2

Active Caspase-3 Antibody

48667-100ul 100ul
EUR 399.6

Active Caspase-3 Antibody

48667-50ul 50ul
EUR 286.8

Active Caspase-3 Antibody

48667 100ul
EUR 499

Active Caspase-3 Rabbit mAb

A11021 20 μL
EUR 18

Active Caspase-3 Rabbit mAb

A11021-100ul 100 ul
EUR 550.8

Active Caspase-3 Rabbit mAb

A11021-200ul 200 ul
EUR 823.2

Active Caspase-3 Rabbit mAb

A11021-20ul 20 ul
EUR 265.2

Active Caspase-3 Rabbit mAb

A11021-50ul 50 ul
EUR 369.6

active Caspase-3 Rabbit pAb

E2380169 100ul
EUR 225
Description: Available in various conjugation types.

active Caspase-3 Rabbit mAb

58542 100ul
EUR 339

Caspase 3 active Antibody

abx200557-100ug 100 ug
EUR 393.6

Active Caspase 8 antibody

10R-8030 100 ug
EUR 669.6
Description: Mouse monoclonal Active Caspase 8 antibody

Active Caspase 9 antibody

70R-11648 100 ug
EUR 774
Description: Rabbit polyclonal Active Caspase 9 antibody

Active Caspase 6 antibody

70R-11655 100 ug
EUR 669.6
Description: Rabbit polyclonal Active Caspase 6 antibody

Active Caspase 8 antibody

70R-11724 100 ug
EUR 523.2
Description: Rabbit polyclonal Active Caspase 8 antibody

active Caspase 3 Antibody

E38PA9132 100ul
EUR 225
Description: Available in various conjugation types.

Apo Active PE - Caspase 3 - - 100 Tests

PAB200-2 100 Tests
EUR 490

Apo Active FITC - Caspase 3 - - 100 Tests

FAB200-2 100 Tests
EUR 490

Active Caspase-1, rat recombinant

7524-100 each
EUR 666

Active Caspase-1, rat recombinant

7524-25 each
EUR 405.6

active+pro Caspase 3 Antibody

48844-100ul 100ul
EUR 399.6

active+pro Caspase 3 Antibody

48844-50ul 50ul
EUR 286.8

active+pro Caspase 3 Antibody

48844 100ul
EUR 499

Caspase-3 Antibody, Pro and Active

N1045-100UG 100 ug
EUR 293.3
Description: Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the 'executioners of apoptosis.' Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 ('initiator caspases') and then effects apoptosis by cleaving targeted cellular proteins.

Caspase-3 Antibody, Pro and Active

N1045-25UG 25 ug
EUR 146.3
Description: Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the 'executioners of apoptosis.' Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 ('initiator caspases') and then effects apoptosis by cleaving targeted cellular proteins.

Red Active Caspase-3 Staining Kit

K2053-100 100 assays
EUR 686.4

Red Active Caspase-3 Staining Kit

K2053-25 25 assays
EUR 285.6

Red Active Caspase-8 Staining Kit

K2054-100 100 assays
EUR 686.4

Red Active Caspase-8 Staining Kit

K2054-25 25 assays
EUR 285.6

Red Active Caspase-9 Staining Kit

K2055-100 100 assays
EUR 686.4

Red Active Caspase-9 Staining Kit

K2055-25 25 assays
EUR 285.6

Red Active Caspase Staining Kit

K2052-100 100 assays
EUR 686.4

Red Active Caspase Staining Kit

K2052-25 25 assays
EUR 285.6

Rat Active caspase 3 ELISA kit

E02A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Active caspase 3 ELISA kit

E02A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Active caspase 3 ELISA kit

E02A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Active caspase 3 ELISA kit

E07A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Active caspase 3 ELISA kit

E07A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Active caspase 3 ELISA kit

E07A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Active caspase 3 ELISA kit

E08A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Active caspase 3 ELISA kit

E08A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Active caspase 3 ELISA kit

E08A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Active Caspase 3 Mouse mAb (4A3)

E2250189 100ul
EUR 225
Description: Available in various conjugation types.

Rat Active caspase 3 ELISA kit

E01A8781 96T
EUR 700
Description: ELISA

Rat Active caspase 1 ELISA kit

E01A10335 96T
EUR 700
Description: ELISA

Rat Active Caspase 9 ELISA kit

E01A10406 96T
EUR 700
Description: ELISA

Goat Active caspase 3 ELISA kit

E06A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Active caspase 3 ELISA kit

E06A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Active caspase 3 ELISA kit

E06A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

active + pro Caspase 3 Rabbit pAb

E2381061 100ul
EUR 225
Description: Available in various conjugation types.

Goat Active caspase 3 ELISA kit

E01A43702 96T
EUR 700
Description: ELISA

Goat Active caspase 1 ELISA kit

E01A45254 96T
EUR 700
Description: ELISA

Goat Active Caspase 9 ELISA kit

E01A45325 96T
EUR 700
Description: ELISA

active + pro Caspase 3 Rabbit mAb

58822 100ul
EUR 339

Rat Caspase 1 (CASP1) Protein (Active)

20-abx651307
  • EUR 1513.20
  • EUR 526.80
  • EUR 5120.40
  • EUR 1846.80
  • EUR 1028.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Polyclonal Caspase-3 (Active) Antibody

APG02385G 0.1mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-3 (Active) . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-7 (Active) Antibody

APG02391G 0.1mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-7 (Active) . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-6 (Active) Antibody

APG02406G 0.1mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-6 (Active) . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-8 (Active) Antibody

APG02408G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-8 (Active) . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 (Active) Antibody

APR00031G 0.1mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 (Active) . This antibody is tested and proven to work in the following applications:

Active Caspase-3 Conjugated Antibody

C48667 100ul
EUR 476.4

Active Caspase-3 Monoclonal Antibody

40491-100ul 100ul
EUR 302.4

Active Caspase-3 Monoclonal Antibody

40491-50ul 50ul
EUR 224.4

Active Caspase-3 Monoclonal Antibody

ABM40197-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of Active Caspase-3 from Human, Mouse, Rat. This Active Caspase-3 antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Active Caspase-3 Monoclonal Antibody

ABM40197-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of Active Caspase-3 from Human, Mouse, Rat. This Active Caspase-3 antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Active Caspase-3 Monoclonal Antibody

ABM40197-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of Active Caspase-3 from Human, Mouse, Rat. This Active Caspase-3 antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen recombinant protein

Active Caspase-3 Monoclonal Antibody

E040491 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Active Caspase-3 Monoclonal Antibody

E20-53431 100ug
EUR 225
Description: Available in various conjugation types.

Active Caspase-3 Monoclonal Antibody

ABM0062-100uL 100 μL
EUR 229
Description: Mouse Anti-Active Caspase-3 Monoclonal Antibody

Active Caspase-3 Monoclonal Antibody

40491 100ul
EUR 319

Mouse Active caspase 3 ELISA kit

E03A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Active caspase 3 ELISA kit

E03A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Active caspase 3 ELISA kit

E03A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Active caspase 3 ELISA kit

E01A95995 96T
EUR 700
Description: ELISA

Sheep Active caspase 1 ELISA kit

E01A97548 96T
EUR 700
Description: ELISA

Sheep Active Caspase 9 ELISA kit

E01A97619 96T
EUR 700
Description: ELISA

Mouse Active caspase 3 ELISA kit

E01A17523 96T
EUR 700
Description: ELISA

Mouse Active caspase 1 ELISA kit

E01A19076 96T
EUR 700
Description: ELISA

Mouse Active Caspase 9 ELISA kit

E01A19147 96T
EUR 700
Description: ELISA

CaspGLOW Active Caspase Staining Kit

55R-1292 25 assays
EUR 355.2
Description: Caspase Staining Kit for use activity in the research laboratory

Active Caspase 8 Blocking Peptide

33R-10690 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Active Caspase 8 antibody, catalog no. 70R-11724

Monkey Active caspase 3 ELISA kit

E09A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Active caspase 3 ELISA kit

E09A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Active caspase 3 ELISA kit

E09A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Active caspase 3 ELISA kit

E04A0015-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Active caspase 3 ELISA kit

E04A0015-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Active caspase 3 ELISA kit

E04A0015-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Active caspase 1 ELISA kit

E01A27822 96T
EUR 700
Description: ELISA

Rabbit Active Caspase 9 ELISA kit

E01A27893 96T
EUR 700
Description: ELISA

Bovine Active caspase 1 ELISA kit

E01A80118 96T
EUR 700
Description: ELISA

Bovine Active Caspase 9 ELISA kit

E01A80189 96T
EUR 700
Description: ELISA

Monkey Active caspase 1 ELISA kit

E01A71401 96T
EUR 700
Description: ELISA

Monkey Active Caspase 9 ELISA kit

E01A71472 96T
EUR 700
Description: ELISA

Bovine Active caspase 3 ELISA kit

E01A78566 96T
EUR 700
Description: ELISA

Canine Active caspase 1 ELISA kit

E01A62688 96T
EUR 700
Description: ELISA

Canine Active Caspase 9 ELISA kit

E01A62759 96T
EUR 700
Description: ELISA

Monkey Active caspase 3 ELISA kit

E01A69849 96T
EUR 700
Description: ELISA

Canine Active caspase 3 ELISA kit

E01A61137 96T
EUR 700
Description: ELISA

Rabbit Active caspase 3 ELISA kit

E01A26270 96T
EUR 700
Description: ELISA

Chicken Active caspase 1 ELISA kit

E01A88844 96T
EUR 700
Description: ELISA

Chicken Active Caspase 9 ELISA kit

E01A88915 96T
EUR 700
Description: ELISA

Chicken Active caspase 3 ELISA kit

E01A87292 96T
EUR 700
Description: ELISA

Porcine Active caspase 1 ELISA kit

E01A53971 96T
EUR 700
Description: ELISA

Porcine Active Caspase 9 ELISA kit

E01A54042 96T
EUR 700
Description: ELISA

Porcine Active caspase 3 ELISA kit

E01A52419 96T
EUR 700
Description: ELISA

Hamster Active caspase 1 ELISA kit

E01A104762 96T
EUR 700
Description: ELISA

Fluorescein Active Caspase-12 Staining Kit

K2046-100 100 assays
EUR 686.4

Collectively, our outcomes might counsel that CPIV3 an infection induced apoptosis and downregulated the degrees of bta-miR-98, and this miRNA regulated viral replication by effected apoptosis. This examine contributes to our understanding of the molecular mechanisms underlying CPIV3 pathogenesis. Essential oil (EO) fractions of vegetation are complicated mixtures of unstable compounds with broad-spectrum organic properties. In the present examine, the EO content material of Vitex agnus castus L. (VAC) leaves rising within the Aegean area of Turkey was extracted and recognized. Then, VAC EOs have been investigated for their potential antioxidant, cytotoxic and apoptotic results in human H69AR multi-drug resistant most cancers cells.