ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-κB dependent cFLIPL expression.

Evidence has proven that almost all hepatocellular carcinoma (HCC) cells are immune to tumor necrosis issue (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. However, the molecular mechanisms underlying TRAIL-mediated apoptosis resistance aren’t nicely understood. In this research, we reported that downregulation of Decoy receptor 3 (DcR3) expression by lentiviral vectors carrying shRNA towards DcR3 (LV-ShDcR3, shDcR3) in …

ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-κB dependent cFLIPL expression. Read More »