Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Water-mediated structural rearrangement establishes active conformation of caspases for apoptosis and inflammation

Caspases are cysteine-dependent aspartate-specific proteases that play a vital function in apoptosis (or programmed cell dying) and inflammation. Based on their perform, caspases are majorly categorized into apoptotic (initiator/apical and effector/executioner) and inflammatory caspases. Caspases bear transition from an inactive zymogen to an active caspase to perform their perform. This transition calls for structural rearrangements that are most …

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