Microplastics (MPs) thought-about as a brand new persistent environmental pollutant may enter into the circulatory system and outcome in lower of sperm amount and high quality in mice. However, the consequences of Polystyrene MPs (PS MPs) on the ovary and its mechanism in rats remained unclear. In this current research, thirty-two wholesome feminine Wistar rats had been uncovered to totally different concentrations of 0.5 µm PS MPs dispersed in deionized water for 90 days. Using hematoxylin-eosin (HE) staining, the quantity of rising follicles was decreased in contrast to the management group.
In addition, the exercise of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD) had been decreased whereas the expression degree of malondialdehyde (MDA) was elevated in ovary tissue. Confirmed by immunohistochemistry, the built-in optical density of NLRP3 and Cleaved-Caspase-1 had been elevated by 13.9 and 14 in granulosa cells in the 1.5 mg/kg/d group. Furthermore, in contrast to the management group, the extent of AMH had been decreased by 23.Three pg/ml whereas IL-1β and IL-18 had been elevated by 32 and 18.5 pg/ml in the 1.5 mg/kg/d group utilizing the enzyme-linked immune sorbent assay (ELISA).
Besides, the apoptosis of granulosa cells was elevated measured by terminal deoxyribonucleotide transferase-mediated nick finish labeling (TUNEL) staining and circulate cytometry. Moreover, western blot assays confirmed that the expressions of NLRP3/Caspase-1 signaling pathway associated elements and Cleaved-Caspase-Three had been elevated. These outcomes demonstrated that PS MPs may induce pyroptosis and apoptosis of ovarian granulosa cells via the NLRP3/Caspase-1 signaling pathway possibly triggered by oxidative stress. The current research prompt that publicity to microplastics had adversarial results on ovary and may very well be a possible danger issue for feminine infertility, which offered new insights into the toxicity of MPs on feminine replica.
The fundamental anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis via the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate most cancers DU-145 cells
Anthocyanins have been reported to have efficient chemopreventive exercise. Lycium ruthenicum Murray is wealthy in anthocyanins and reveals many organic actions. The objective of this research was to examine the consequences and attainable organic mechanism of the principle anthocyanin monomer (Pt3G) of Lycium ruthenicum Murray on prostate most cancers DU-145 cells. The cell proliferation was detected by methyl thiazolyl tetrazolium assay. The cell apoptosis charges had been assessed by circulate cytometric evaluation and TUNEL assay.
The expressions of apoptosis associated proteins had been evaluated by western blotting. Our knowledge demonstrated that Pt3G inhibited cell proliferation, induced apoptosis and promoted cell cycle arrest on the S section in a concentration-dependent method (0, 100, 200 and 400 μg mL-1). Furthermore, it was proven that Pt3G decreased the mitochondrial membrane permeability via regulating the expressions of Bax and Bcl-2. Western blot evaluation indicated that Pt3G considerably elevated the expression of PTEN and then activated the PI3K/Akt-mediated caspase 3 pathway.
In addition, our outcomes additionally prompt that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS. To sum up, these outcomes point out that Pt3G inhibits cell proliferation and induces apoptosis via the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate most cancers DU-145 cells. Therefore, Pt3G of Lycium ruthenicum Murray could also be a possible anti-proliferative agent for the prevention or therapy of prostate most cancers.
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial most cancers cells in vitro
Previously we’ve proven inhibition of endometrial most cancers cell development with progesterone and calcitriol. However, the mechanisms by which the 2 brokers attenuate proliferation haven’t been properly characterised but. Herein, we investigated how progesterone and calcitriol induce apoptosis in most cancers cells. DNA fragmentation was upregulated by progesterone and calcitriol in ovarian and endometrial most cancers cells.
Time-dependent therapy of ovarian most cancers cells, ES-2, and TOV-21G with progesterone enhanced caspase -Eight exercise after 12 h, whereas OV-90, TOV-112D, HEC-1A, and HEC-59 cells confirmed elevated exercise after 24 h. Caspase 9 exercise was elevated in all cell strains after 24 h therapy with calcitriol. Pretreatment of most cancers cells with a caspase-Eight inhibitor (z-IETD-fmk) or caspase-9 inhibitor (Z-LEHD-fmk) considerably attenuated progesterone and calcitriol induced caspase-8 and caspase-9 expression, respectively. The expression of FasL, Fas, FAD, and pro-caspase-8, which represent the death-inducing signaling complicated (DISC), was upregulated in progesterone handled most cancers cells.
Knockdown of FAS or FADD with particular siRNAs considerably blocked progesterone-induced caspase-8. Cleavage of the BID was not affected by caspase-Eight activation suggesting the absence of cross-talk between caspase-8 and caspase-9 pathways. Calcitriol therapy decreased mitochondrial membrane potential and elevated the discharge of most cancers cytochrome C. These findings point out that progesterone induces apoptosis via activation of caspase-8 and calcitriol via caspase-9 activation in most cancers cells. A mixture of progesterone-calcitriol prompts each extrinsic and intrinsic apoptotic pathways in most cancers cells.
 Antibody) Factor Related Apoptosis (FAS) Antibody |
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| 20-abx102358 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx102359 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx102360 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx104789 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx128470 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx129940 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx130140 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx130850 | Abbexa |
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 Antibody) Factor Related Apoptosis (Fas) Antibody |
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| abx038135-100ug | Abbexa | 100 ug | EUR 469.2 |
Factor Related Apoptosis (FAS) Antibody |
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| 20-abx270037 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx270229 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx172320 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx172321 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| 20-abx176352 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody |
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| abx430025-200ul | Abbexa | 200 ul | EUR 460.8 |
 Antibody (PE)) Factor Related Apoptosis (FAS) Antibody (PE) |
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| 20-abx270799 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (PE) |
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| 20-abx270991 | Abbexa |
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 Antibody (APC)) Factor Related Apoptosis (FAS) Antibody (APC) |
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| 20-abx270567 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (APC) |
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| 20-abx270759 | Abbexa |
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 Antibody Pair) Factor Related Apoptosis (FAS) Antibody Pair |
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| abx117346-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
 Antibody (FITC)) Factor Related Apoptosis (FAS) Antibody (FITC) |
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| 20-abx273863 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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| 20-abx270335 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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| 20-abx270527 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (FITC) |
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| 20-abx274177 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody Pair |
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| 20-abx370099 | Abbexa |
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 Antibody (Biotin)) Factor Related Apoptosis (FAS) Antibody (Biotin) |
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| 20-abx271895 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (Biotin) |
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| 20-abx272642 | Abbexa |
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Factor Related Apoptosis (FAS) Antibody (Biotin) |
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| 20-abx273127 | Abbexa |
|
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 Antibody) Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx103238 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx103239 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx103240 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx103241 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx129724 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx270062 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx270167 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx172322 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx176353 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| 20-abx176354 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103238-100l | Abbexa | 100 µl | EUR 212.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103238-1ml | Abbexa | 1 ml | EUR 475 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103238-200l | Abbexa | 200 µl | EUR 250 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103239-100l | Abbexa | 100 µl | EUR 212.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103239-1ml | Abbexa | 1 ml | EUR 475 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103239-200l | Abbexa | 200 µl | EUR 250 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103240-100l | Abbexa | 100 µl | EUR 262.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103240-1ml | Abbexa | 1 ml | EUR 725 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103240-200l | Abbexa | 200 µl | EUR 337.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103241-100l | Abbexa | 100 µl | EUR 300 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103241-1ml | Abbexa | 1 ml | EUR 875 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx103241-200l | Abbexa | 200 µl | EUR 375 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx129724-100l | Abbexa | 100 µl | EUR 212.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx129724-1ml | Abbexa | 1 ml | EUR 475 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx129724-200l | Abbexa | 200 µl | EUR 250 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx172322-100l | Abbexa | 100 µl | EUR 625 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx172322-1ml | Abbexa | 1 ml | Ask for price |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx172322-200l | Abbexa | 200 µl | Ask for price |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx176354-1096tests | Abbexa | 10 × 96 tests | EUR 812.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx176354-596tests | Abbexa | 5 × 96 tests | EUR 362.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx176354-96tests | Abbexa | 96 tests | EUR 287.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx270062-1ml | Abbexa | 1 ml | EUR 387.5 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx270062-200l | Abbexa | 200 µl | EUR 275 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx270167-1ml | Abbexa | 1 ml | EUR 425 |
Factor Related Apoptosis Ligand (FASL) Antibody |
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| abx270167-200l | Abbexa | 200 µl | EUR 300 |
 Polyclonal Antibody) Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28926-100ul | Biomatik Corporation | 100ul | EUR 224.6 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28926-200ul | Biomatik Corporation | 200ul | EUR 280.6 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28927-100ul | Biomatik Corporation | 100ul | EUR 204.5 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28927-200ul | Biomatik Corporation | 200ul | EUR 255.4 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28928-100ul | Biomatik Corporation | 100ul | EUR 204.5 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28928-200ul | Biomatik Corporation | 200ul | EUR 255.4 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28929-100ul | Biomatik Corporation | 100ul | EUR 204.5 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28929-200ul | Biomatik Corporation | 200ul | EUR 255.4 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28930-100ul | Biomatik Corporation | 100ul | EUR 254.4 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28930-200ul | Biomatik Corporation | 200ul | EUR 317.5 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28931-100ul | Biomatik Corporation | 100ul | EUR 193.9 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28931-200ul | Biomatik Corporation | 200ul | EUR 241.9 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28932-100ul | Biomatik Corporation | 100ul | EUR 193.9 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28932-200ul | Biomatik Corporation | 200ul | EUR 241.9 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28933-100ul | Biomatik Corporation | 100ul | EUR 188.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28933-200ul | Biomatik Corporation | 200ul | EUR 235.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28934-100ul | Biomatik Corporation | 100ul | EUR 188.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28934-200ul | Biomatik Corporation | 200ul | EUR 235.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28935-100ul | Biomatik Corporation | 100ul | EUR 188.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28935-200ul | Biomatik Corporation | 200ul | EUR 235.2 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28936-100ul | Biomatik Corporation | 100ul | EUR 254.4 |
Factor Related Apoptosis (FAS) Polyclonal Antibody |
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| CAU28936-200ul | Biomatik Corporation | 200ul | EUR 317.5 |
 Monoclonal Antibody) Factor Related Apoptosis (FAS) Monoclonal Antibody |
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| CAU30571-100ul | Biomatik Corporation | 100ul | EUR 217.9 |
Factor Related Apoptosis (FAS) Monoclonal Antibody |
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| CAU30571-200ul | Biomatik Corporation | 200ul | EUR 272.2 |
 Antibody (PE)) Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| 20-abx270824 | Abbexa |
|
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Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| 20-abx270929 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| abx270824-1ml | Abbexa | 1 ml | EUR 1125 |
Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| abx270824-200l | Abbexa | 200 µl | EUR 687.5 |
Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| abx270929-1ml | Abbexa | 1 ml | EUR 1125 |
Factor Related Apoptosis Ligand (FASL) Antibody (PE) |
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| abx270929-200l | Abbexa | 200 µl | EUR 687.5 |
 Antibody (APC)) Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| 20-abx270592 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| 20-abx270697 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| abx270592-1ml | Abbexa | 1 ml | EUR 1312.5 |
Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| abx270592-200l | Abbexa | 200 µl | EUR 800 |
Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| abx270697-1ml | Abbexa | 1 ml | EUR 1312.5 |
Factor Related Apoptosis Ligand (FASL) Antibody (APC) |
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| abx270697-200l | Abbexa | 200 µl | EUR 800 |
 Antibody (FITC)) Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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| 20-abx270360 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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| 20-abx270465 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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| 20-abx274189 | Abbexa |
|
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 Antibody) Factor Related Apoptosis / CD95 / TNFRSF6 (FAS) Antibody |
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| abx412230-50ug | Abbexa | 50 ug | EUR 610.8 |
 Antibody Pair) Factor Related Apoptosis Ligand (FASL) Antibody Pair |
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| 20-abx370039 | Abbexa |
|
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Factor Related Apoptosis Ligand (FASL) Antibody Pair |
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| 20-abx370239 | Abbexa |
|
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Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
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| abx270360-1ml | Abbexa | 1 ml | EUR 912.5 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
|||
| abx270360-200l | Abbexa | 200 µl | EUR 575 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
|||
| abx270465-1ml | Abbexa | 1 ml | EUR 912.5 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
|||
| abx270465-200l | Abbexa | 200 µl | EUR 575 |
Factor Related Apoptosis Ligand (FASL) Antibody (FITC) |
|||
| abx274189-05ml | Abbexa | 0.5 ml | EUR 487.5 |
Factor Related Apoptosis Ligand (FASL) Antibody Pair |
|||
| abx370039-100g | Abbexa | 100 µg | EUR 975 |
Factor Related Apoptosis Ligand (FASL) Antibody Pair |
|||
| abx370239-100g | Abbexa | 100 µg | EUR 975 |
) Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Bo01 | Cloud-Clone | 100ul | EUR 265 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Hu01 | Cloud-Clone | 100ul | EUR 196 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Hu02 | Cloud-Clone | 100ul | EUR 196 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Hu03 | Cloud-Clone | 100ul | EUR 196 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Mu01 | Cloud-Clone | 100ul | EUR 202 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Mu02 | Cloud-Clone | 100ul | EUR 202 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Po01 | Cloud-Clone | 100ul | EUR 265 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Ra01 | Cloud-Clone | 100ul | EUR 213 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Ra02 | Cloud-Clone | 100ul | EUR 213 |
Polyclonal Antibody to Factor Related Apoptosis (FAS) |
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| PAA030Ra03 | Cloud-Clone | 100ul | EUR 213 |
 Antibody (Biotin)) Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
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| 20-abx271896 | Abbexa |
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Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
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| 20-abx273435 | Abbexa |
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 Polyclonal Antibody (Pig)) Factor Related Apoptosis (FAS) Polyclonal Antibody (Pig) |
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| 4-PAA030Po01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Pig Factor Related Apoptosis (FAS) |
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 Polyclonal Antibody (Rat)) Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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| 4-PAA030Ra01 | Cloud-Clone |
|
|
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
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Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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| 4-PAA030Ra02 | Cloud-Clone |
|
|
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
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Factor Related Apoptosis (FAS) Polyclonal Antibody (Rat) |
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| 4-PAA030Ra06 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Factor Related Apoptosis (FAS) |
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Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
|||
| abx271896-1ml | Abbexa | 1 ml | EUR 525 |
Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
|||
| abx271896-200l | Abbexa | 200 µl | EUR 275 |
Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
|||
| abx273435-250mg | Abbexa | 250 mg | EUR 950 |
Factor Related Apoptosis Ligand (FASL) Antibody (Biotin) |
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| abx273435-50mg | Abbexa | 50 mg | EUR 400 |
 Antibody) Factor Related Apoptosis Ligand / TNFSF6 (FASLG) Antibody |
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| abx233016-100ug | Abbexa | 100 ug | EUR 661.2 |
Factor Related Apoptosis Ligand / TNFSF6 (FASLG) Antibody |
|||
| abx233017-100ug | Abbexa | 100 ug | EUR 610.8 |
Factor Related Apoptosis Ligand / TNFSF6 (FASLG) Antibody |
|||
| abx376345-96tests | Abbexa | 96 tests | EUR 225 |
 Polyclonal Antibody (Human)) Factor Related Apoptosis (FAS) Polyclonal Antibody (Human) |
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| 4-PAA030Hu01 | Cloud-Clone |
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|
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Description: A Rabbit polyclonal antibody against Human Factor Related Apoptosis (FAS) |
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Deoxynivalenol (DON) is a typical trichothecene mycotoxin discovered worldwide. DON has broad toxicity in direction of animals and people. However, the mechanism of DON-induced neurotoxicity in vitro has not been absolutely understood. This research investigated the speculation that DON toxicity in neurons happens via the mitochondrial apoptotic pathway. Using piglet hippocampal nerve cells (PHNCs), we evaluated the consequences of totally different concentrations of DON on typical indicators of apoptosis.